China Corona Virus Outbreak

[uls]

may local transmission na ng b117

[dr. d]

may local transmission na ng b117

sino nahawa kanino?

[uls]

sino nahawa kanino?

results from genome sequencing -- more than a dozen people have that variant

some of them have no contact with known infected and no travel outside PH

so there's local transmission na

[shadow]

results from genome sequencing -- more than a dozen people have that variant

some of them have no contact with known infected and no travel outside PH

so there's local transmission na

Paano nga nakuha kung walang travel and contact sa infected


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[ninjababez]

Wearing double mask + face shield = ultimate protection?

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probably, pero i think very small percentage (of protection) nalang madagdag mo dun sa initial mask eh
yun face shield kasi according to studies daw does not really help to be inconvenience by wearing it
sa resto lang when people eat (guilty rin ako), nilalapag mo sa lamesa. na di ka sure if na disinfect ba ng maigi

[dr. d]

results from genome sequencing -- more than a dozen people have that variant

some of them have no contact with known infected and no travel outside PH

so there's local transmission na

can we not attribute it to spontaneous, natural mutation, instead?
i mean, the mutant does not have to be imported in the first place, if that is what is being alluded. it was probably created here.

if it happened in the UK,
why can't it happen here and elsewhere?

[dr. d]

probably, pero i think very small percentage (of protection) nalang madagdag mo dun sa initial mask eh
yun face shield kasi according to studies daw does not really help to be inconvenience by wearing it
sa resto lang when people eat (guilty rin ako), nilalapag mo sa lamesa. na di ka sure if na disinfect ba ng maigi

if the fabric mask leaks like the proverbial sieve, then the primary protection is still the surgical mask underneath.

face shield.
who else, aside from the philippines, dons face shield as a matter of policy?

[111prez]

The WHO on fabric masks: Fabric facemasks still work against virus variants —WHO

[uls]

Paano nga nakuha kung walang travel and contact sa infected


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meron undetected community transmission

nahawa sila sa meron virus na walang nakakaalam na new variant

maari 2nd or 3rd generation contact ng imported cases

di malalaman na new variant unless nag genome sequencing

maari din ung sinabi ni doc na ang mutation nangyari din sa atin na pareho 501Y mutation

[Flipo]

The good news, however, is that “second generation” vaccines are being developed by researchers, many of whom are working with novel techniques. “We have an embarrassment of riches,” Altmann says. “One thing that certainly hasn’t been appreciated by most people is that, on the back burner, the field of vaccinology has been steaming ahead over the past 15 years, developing a range of incredibly snazzy strategies.”

There are nearly 240 novel vaccine candidates in development, waiting in the wings for their moment. Here are a few that show the most potential.
Self-Amplifying RNA (Imperial College London)

Similar to the approved mRNA vaccines, this one inserts genetic material from the virus directly into human cells, spurring the body to manufacture the famed “spike” protein that covers the surface of SARS-CoV-2. And like mRNA vaccines, Imperial College London’s design only delivers the genetic material, not the actual virus, so it is unlikely to exacerbate illness if people are infected following vaccination. The twist with this vaccine is that it has been modified to turn the body’s own cells into factories that continually churn out spike proteins on their own—meaning a booster shot will not be necessary. Moreover, such “self-amplifying” RNA can reportedly be made in huge volumes for little cost. “I feel very excited about the way [this approach] may turn out to be like Pfizer’s and Moderna’s vaccines but even better,” says Altmann, who was not directly involved in developing this vaccine.
Protein Subunit (Novavax)

Researchers at the Maryland-based start-up Novavax have focused on delivering the actual spike protein itself (rather than a whole virus or genetic material). They created the vaccine by engineering moth cells to churn out spike proteins in bioreactors at low cost. Furthermore, this vaccine can be kept at two to eight degrees C—normal refrigeration temperature—making it far more practical to distribute. The trick with this approach is the addition of an “adjuvant”—an additive that “soups up” the immune system’s response—made from saponin, a compound derived from the bark of the Chilean soapbark tree. “Engineered protein technology has been tested and proved in the past—it just takes a little more time to produce than RNA,” explains Gregory Glenn, president of research and development at Novavax.
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Like Novavax, University of Washington researchers have chosen to deliver proteins from SARS-CoV-2 as their weapon of choice. But instead of injecting the entire spike protein, they have homed in on the virus’s “Achilles’ heel”: the receptor binding domain (RBD), the portion of the spike protein that directly fuses with human cells. Neil King, a biochemist at the university’s Institute for Protein Design, has created a vaccine delivered by spherical “nanoparticles” shaped like soccer balls. Synthetically manufactured RBD proteins are affixed to the nanoparticles in regular arrays. This design makes the vaccine capable of eliciting antibody responses at least 10 times higher than those that use the whole, natural spike protein, King says. “We aren’t just taking existing proteins and tweaking them a little bit—we are making completely new ones to do exactly what we want,” he notes. The vaccine is currently being tested in early-stage, or phase I, trials with human volunteers. If successful, it could reach the public later this year.

Other Vaccines in the Pipeline

These are just a few of the vaccine candidates in development. Others that could help slow the pandemic, including the vaccine developed by Sinovac Biotech in China, utilize more conventional designs, such as an inactivated virus (a technique used to help conquer polio and still used in many influenza vaccines). It remains to be seen how well all of these approaches may work. But with so many efforts underway, there is good reason to hope that the end of this pandemic nightmare is in sight.

And when it does end, scientists will have many tools ready-made for when the next pandemic hits.


The Second-Generation COVID Vaccines Are Coming - Scientific American

[uls]

ung 501Y mutation nangyari independently sa UK (501Y.V1), South Africa (501Y.V2), Brazil (501Y.V3)

so it can happen elsewhere

it just so happened UK does a lot of genome sequencing kaya sila una nakadetect ng ganyan variant

that doesn't necessarily mean sila ang nauna nagkaroon

it's inevitable magkakaroon ng bagong variants coz the virus mutates

buti nalang it doesn't mutate as much as HIV (kaya wala pa vaccine ang HIV)

--

nature will favor versions with higher survival advantage

since the virus has been challenged by human immune systems for a year already the stronger versions will replace the weaker versions

(weaker versions get neutralized by our immune system, stronger versions escape neutralization)

[uls]

kaya di ko alam baket puro bakuna ang pinag uusapan sa media + socmed

those 1st gen vaccines were developed based on very early variants of the virus -- as is January 2020 variant

baka maging obsolete mga yan within the year

[_Cathy_]

This thread used to give me severe anxiety but not so much anymore.

As long as I wear my face mask (surgical 4 ply mask), NEVER remove it while I am out, and go to places where face masks are mandatory, I don't feel so paranoid anymore. However, I still refuse to go to a clinic, lab or hospital. I go out na to buy fruits and veggies for fat lab and some errands. I don't wear face shield (unless required)

I'm thinking of doing the double mask pero baka naman kasi kumapit pa virus sa fabric mask and I have to wash that off, I prefer disposable masks. Double surgical kaya? I have a few N95 from the US, I am saving it for when I fly back to the US. I think 8 hrs na efficacy ng face mask?

[dr. d]

kaya di ko alam baket puro bakuna ang pinag uusapan sa media + socmed

those 1st gen vaccines were developed based on very early variants of the virus -- as is January 2020 variant

baka maging obsolete mga yan within the year

... because there's not much of an alternative in the horizon...?

if we keep on waiting for the next mutation,
we'll never get started vaccinating.

[Monseratto]

California virus variant driving surge around LA; smell training advised for lingering problem | Reuters

Virus variant found in California drives SoCal surge

A new variant of the coronavirus appears to account for the recent surge of cases in southern California, researchers say. The variant, called CAL.20C, accounted for fewer than one in every 1,000 COVID-19 cases in Los Angeles county in July. It was not detected again until October, but by December accounted for 36% of cases, researchers from Cedars-Sinai Medical Center in Los Angeles reported on Wednesday on medRxiv ahead of peer review. The CAL.20C variant is distinct from those discovered in the UK, South Africa and Brazil. It carries five mutations: three in the spike protein, which the virus uses to break into cells, and two in other parts of the virus. CAL.20C has also been detected in northern California, New York and Washington, DC. Whether it is more easily transmissible or resistant to antibodies than earlier versions of the virus is not yet known. The researchers intend to "mine the data and see how patients do over time," coauthor Jasmine Plummer said. The proliferation of CAL.20C in November and December shows that "we allowed it to emerge during the holidays," she said. "These kind of numbers reinforce that we need to wear masks, socially isolate, and stay home." (bit.ly/2No1HcR)

[ale828]

This thread used to give me severe anxiety but not so much anymore.

As long as I wear my face mask (surgical 4 ply mask), NEVER remove it while I am out, and go to places where face masks are mandatory, I don't feel so paranoid anymore. However, I still refuse to go to a clinic, lab or hospital. I go out na to buy fruits and veggies for fat lab and some errands. I don't wear face shield (unless required)

I'm thinking of doing the double mask pero baka naman kasi kumapit pa virus sa fabric mask and I have to wash that off, I prefer disposable masks. Double surgical kaya? I have a few N95 from the US, I am saving it for when I fly back to the US. I think 8 hrs na efficacy ng face mask?

going out during these times is just a matter of careful planning. Limit time inside malls and enclosed places, avoid crowded areas in the mall as much as possible. refrain from using the elevator if possible, If you really need to eat, do so al fresco with social distancing or at least a restaurant with a big open area with minimal customers. Refrain from going to public restrooms, if you can use the pay lounge restrooms.

Tried double mask (surical +cloth) before and there still seems to be open spaces between the first surgical mask and your skin plus i find it slightly harder to breathe . i would still prefer a tight N95 mask than the double mask.


Philippines detects 16 more cases of new COVID-19 variant | Philstar.com

since Dec 29, 2020 yung isang patient with UK variant dumating sa pinas.
the first one na may UK variant na news arrived from the emirates flight january 7.

[_Cathy_]

going out during these times is just a matter of careful planning. Limit time inside malls and enclosed places, avoid crowded areas in the mall as much as possible. refrain from using the elevator if possible, If you really need to eat, do so al fresco with social distancing or at least a restaurant with a big open area with minimal customers. Refrain from going to public restrooms, if you can use the pay lounge restrooms.

Tried double mask (surical +cloth) before and there still seems to be open spaces between the first surgical mask and your skin plus i find it slightly harder to breathe . i would still prefer a tight N95 mask than the double mask.


Philippines detects 16 more cases of new COVID-19 variant | Philstar.com

since Dec 29, 2020 yung isang patient with UK variant dumating sa pinas.
the first one na may UK variant na news arrived from the emirates flight january 7.

That is so true! I try to do everything in just one day. I never use the elevator too and restrooms, that's why when I am out I don't drink, eat or pee the whole time (never take off my mask) It's kinda rude nga that I do not eat at all but I explain naman na I am high risk kasi

I would like to buy N95 sana but there are too many fakes

[111prez]

Looks like India is serious in its pushback: Myanmar receives first batch of COVID-19 vaccines from India | ABS-CBN News

[uls]

Shipments of AstraZeneca’s vaccine manufactured by the Serum Institute of India, the world's biggest producer of vaccines, have already gone to the Maldives, Bhutan, Bangladesh and Nepal.

Myanmar was among the countries next in line to get free consignments as India moved before China which has also pledged to supply vaccines to its neighbor.

haha

dahil sa geopolitics hindi priority ang delivery ng AZN vaccine to PH

puro AZN vaccine pa naman ang order ng mga LGU and private sector

hintay muna Pinas ha...

[uls]

parang antagal naman ng delivery ng AZN vaccine na inorder nila Joey Concepcion

last year pa yan eh