China Corona Virus Outbreak

[Monseratto]

14 percent of the total is positive in QC

[uls]

re convalescent plasma

somebody should just isolate the immunoglobulins and put them in vials

[shadow]

Anong breakdown? Ilan doon sa 199 galing sa NCR?


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[dr. d]

re convalescent plasma

somebody should just isolate the immunoglobulins and put them in vials

that is the ideal. ganyan nga ang ginagawa sa commercially prepared immunoglobins.

however,
it would be too expensive to do that right now.
transfusing the donated plasma of the convalescent, is easier, cheaper, less complicated, and less labor-and-technology-intensive. it is, essentially, more practical.

[dhisky]

sorry sa mga taga QC and Manila pero sana iextend pa ito until end of this month.

Just curious, ano specialization doc dr. d?

[Monseratto]

[dr. d]

sorry sa mga taga QC and Manila pero sana iextend pa ito until end of this month.

Just curious, ano specialization doc dr. d?

oh...
here and there.
let's leave it at that.

much of what i post, are stock textbook knowledge that every decent medical graduate should know.
also, it is much easier for us to google medical literature, because MDs understand them more than non-MDs.

[dreamur]

Are we adopting the same playbook?

'''Put on a mask and shut up''': China'''s new '''Wolf Warriors''' spread hoaxes and attack a world of critics

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[_Cathy_]

Ano sa tingin niyo? Ma extend ang ECQ until May 31? Medyo natatawa lang ako sa level of paranoid ng friends ko kasi seryoso sa face mask + goggles + face shield, naalala ko si shadow! hahaha!

[shadow]

Ano sa tingin niyo? Ma extend ang ECQ until May 31? Medyo natatawa lang ako sa level of paranoid ng friends ko kasi seryoso sa face mask + goggles + face shield, naalala ko si shadow! hahaha!

Face mask lang ako and Googles or face shield. Hinde naman sabay goggles and face shield. [emoji23]


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[dr. d]

Ano sa tingin niyo? Ma extend ang ECQ until May 31? Medyo natatawa lang ako sa level of paranoid ng friends ko kasi seryoso sa face mask + goggles + face shield, naalala ko si shadow! hahaha!

of course i'm scared to death! everyone should be.
we have over 637 reported covid-caused deaths! probably more being un-reported. that's over 100 deaths a month!
those doctors that died and those still detained in the hospital...? a number of them are my friends.
we still don't know why some died and why others did not die.
i won't laugh if some folks walked around in full-body suits.

extend?
let's find out next week.

[uls]

thread

Twitter

My dad is an ICU doctor treating COVID-19 patients. In the past WEEK he has set more “I’ve never seen a heart rate/RBC count/etc. like this” records than in his decades-long career. What this virus does to the body is like “sticking your finger in an electric socket.” Stay home.

He had a patient who needed 8 blood transfusions in a morning even though he wasn’t bleeding. The coronavirus was just eating his red blood cells faster than his bone marrow could make them. It’s f*cking mystifying and brutal.

EIGHT. Eight blood transfusions.

If you are lucky enough to make it off a ventilator (the equivalent exertion required for that is running a marathon without training), you will likely get put on dialysis and a feeding tube next. It’s a nightmare. It’s hell. It’s what you’re risking on your beach day.

Young, healthy people are dying from a COVID-19 effect called a "cytokine storm." Basically, you make it off a ventilator (maybe!), you get your appetite back a little, you think you're turning a corner, and then your immune system rips through your lung tissue and you drown.

The other common way young people are falling off the face of the earth from this are the random strokes it causes. Talking one minute, stroking out the next, and then the nurses have to go through the cell phone to find "Dad" because "Mom" usually insists on coming.

There have been a few "Papa Bear"s or "Daddy-O"s in the cell phones who have tried to come in to hold the bodies.

They can't, of course. You die alone from COVID. And you will be buried alone. Stay home.

Send this thread to any idiot f*cker who posts an Instagram at the beach or a crowded park. Tell them my dad says see you later.

Also have an advanced directive because a lot of fiancés and parents are being put in UNCOMFORTABLE situations deciding. Truly, before you head to the crowded beach or nail salon or bowling alley, decide if you're a chest compressions guy or feeding tube vegetable queen.

[uls]

sorry sa mga taga QC and Manila pero sana iextend pa ito until end of this month.

QC ako and that's not gonna happen

we reopen in 10 days

i'm tired of staying home

these guys can carry my coffin

[uls]

learning something new about this virus everyday

guess what

we need push back the timeline

this is legit peer-reviewed

SARS-COV-2 was already spreading in France in late December 219 - ScienceDirect

Abstract
The COVID-19 epidemic is believed to have started in late January 2020 in France. We report here a case of a patient hospitalized in December 2019 in our intensive care, of our hospital in the north of Paris, for hemoptysis with no etiological diagnosis and for which RT-PCR was performed retrospectively on the stored respiratory sample which confirmed the diagnosis of COVID-19 infection. Based on this result, it appears that the COVID-19 epidemic started much earlier.

[uls]

https://www.thelocal.se/20200505/the...en-in-november

It's likely that there were individual cases of coronavirus in Sweden as early as November 2019, according to the Public Health Agency, but the country is not currently working to trace the earliest cases.

The news follows a report from France that a man was infected with the coronavirus on December 27th, several days before the first cases were reported in China. The patient was diagnosed with pneumonia but a sample taken at the time has now tested positive for the coronavirus. That man has fully recovered since his illness, but reportedly has no idea how he caught the virus.

Now state epidemiologist Anders Tegnell has said there were likely infected individuals in Sweden at this time too.

"There wasn't any spread [of infection] outside Wuhan until we saw it in Europe later. But I think that you could find individual cases among Wuhan travellers who were there in November to December last year. That doesn't sound at all strange, but rather very natural," said Tegnell.

Currently the first confirmed case of the virus in Sweden was a woman in Jönköping who tested positive on January 31st after a recent trip to China. She has since recovered from the illness.

so the virus could have been spreading in Wuhan earlier than November... maybe October

[falken]

Scientists say a now-dominant strain of the coronavirus appears to be more contagious than original




Scientists say a now-dominant strain of the coronavirus appears to be more contagious than original

Ralph Vartabedian

May 5, 2020, 7:00 PM GMT+8


An image from an electron microscope shows SARS-CoV-2, the virus that causes COVID-19. Scientists say this version of the coronavirus has mutated and become more contagious. (Associated Press)
Scientists have identified a new strain of the coronavirus that has become dominant worldwide and appears to be more contagious than the versions that spread in the early days of the COVID-19 pandemic, according to a new study led by scientists at Los Alamos National Laboratory.
The new strain appeared in February in Europe, migrated quickly to the East Coast of the United States and has been the dominant strain across the world since mid-March, the scientists wrote.

In addition to spreading faster, it may make people vulnerable to a second infection after a first bout with the disease, the report warned.
The 33-page report was posted Thursday on BioRxiv, a website that researchers use to share their work before it is peer reviewed, an effort to speed up collaborations with scientists working on COVID-19 vaccines or treatments. That research has been largely based on the genetic sequence of earlier strains and might not be effective against the new one.
The mutation identified in the new report affects the now infamous spikes on the exterior of the coronavirus, which allow it to enter human respiratory cells. The report's authors said they felt an "urgent need for an early warning" so that vaccines and drugs under development around the world will be effective against the mutated strain.
Wherever the new strain appeared, it quickly infected far more people than the earlier strains that came out of Wuhan, China, and within weeks it was the only strain that was prevalent in some nations, according to the report. The new strain's dominance over its predecessors demonstrates that it is more infectious, according to the report, though exactly why is not yet known.
The coronavirus, known to scientists as SARS-CoV-2, has infected more than 3.5 million people around the world and caused more than 250,000 COVID-19 deaths since its discovery late last year.
The report was based on a computational analysis of more than 6,000 coronavirus sequences from around the world, collected by the Global Initiative for Sharing All Influenza Data, a public-private organization in Germany. Time and again, the analysis found the new version was transitioning to become dominant.
The Los Alamos team, assisted by scientists at Duke University and the University of Sheffield in England, identified 14 mutations. Those mutations occurred among the nearly 30,000 base pairs of RNA that other scientists say make up the coronavirus's genome. The report authors focused on a mutation called D614G, which is responsible for the change in the virus' spikes.
"The story is worrying, as we see a mutated form of the virus very rapidly emerging, and over the month of March becoming the dominant pandemic form," study leader Bette Korber, a computational biologist at Los Alamos, wrote on her Facebook page. "When viruses with this mutation enter a population, they rapidly begin to take over the local epidemic, thus they are more transmissible."
While the Los Alamos report is highly technical and dispassionate, Korber expressed some deep personal feelings about the implications of the finding in her Facebook post.
"This is hard news," wrote Korber, "but please don’t only be disheartened by it. Our team at LANL was able to document this mutation and its impact on transmission only because of a massive global effort of clinical people and experimental groups, who make new sequences of the virus (SARS-CoV-2) in their local communities available as quickly as they possibly can."

Korber, a graduate of Cal State Long Beach who went on to earn a PhD in chemistry at Caltech, joined the lab in 1990 and focused much of her work on an HIV vaccine. In 2004, she won the Ernest Orlando Lawrence Award, the U.S. Department of Energy's highest recognition for scientific achievement. She contributed a portion of the financial prize to help establish an orphanage for young AIDS victims in South Africa.
The report contains regional breakdowns of when the new strain of virus first emerged and how long it took to become dominant.
Italy was one of the first countries to see the new virus in the last week of February, almost at the same time that the original strain appeared. Washington was among the first states to get hit with the original strain in late February, but by March 15 the mutated strain dominated. New York was hit by the original virus around March 15, but within days the mutant strain took over. The team did not report results for California.
Scientists at major organizations working on a vaccine or drugs have told The Times that they are pinning their hopes on initial evidence that the virus is stable and not likely to mutate the way influenza virus does, requiring a new vaccine every year. The Los Alamos report could upend that assumption.
If the pandemic fails to wane seasonally as the weather warms, the study warns, the virus could undergo further mutations even as research organizations prepare the first medical treatments and vaccines. Without getting on top of the risk now, the effectiveness of vaccines could be limited. Some of the compounds in development are supposed to latch onto the spike or interrupt its action. If they were designed based on the original version of the spike, they might not be effective against the new coronavirus strain, the study's authors warned.
"We cannot afford to be blindsided as we move vaccines and antibodies into clinical testing," Korber wrote on Facebook. "Please be encouraged by knowing the global scientific community is on this, and we are cooperating with each other in ways I have never seen … in my 30 years as a scientist."
David Montefiori, a Duke University scientist who worked on the report said it is the first to document a mutation in the coronavirus that appears to make it more infectious.
Although the researchers don’t yet know the details about how the mutated spike behaves inside the body, it’s clearly doing something that gives it an evolutionary advantage over its predecessor and is fueling its rapid spread. One scientist called it a "classic case of Darwinian evolution."
"D614G is increasing in frequency at an alarming rate, indicating a fitness advantage relative to the original Wuhan strain that enables more rapid spread," the study said.
Still unknown is whether this mutant virus could account for regional variations in how hard COVID-19 is hitting different parts of the world.
In the United States, doctors had begun to independently question whether new strains of the virus could account for the differences in how it has infected, sickened and killed people, said Alan Wu, a UC San Francisco professor who runs the clinical chemistry and toxicology laboratories at San Francisco General Hospital.
Medical experts have speculated in recent weeks that they were seeing at least two strains of the virus in the U.S., one prevalent on the East Coast and another on the West Coast, according to Wu.
“We are looking to identify the mutation,” he said, noting that his hospital has had only a few deaths out of the hundreds of cases it has treated, which is “quite a different story than we are hearing from New York."
The Los Alamos study does not indicate that the new version of the virus is more lethal than the original. People infected with the mutated strain appear to have higher viral loads. But the study's authors from the University of Sheffield found that among a local sample of 447 patients, hospitalization rates were about the same for people infected with either virus version.
Even if the new strain is no more dangerous than the others, it could still complicate efforts to bring the pandemic under control. That would be an issue if the mutation makes the virus so different from earlier strains that people who have immunity to them would not be immune to the new version.
If that is indeed the case, it could make "individuals susceptible to a second infection," the study authors wrote.
It’s possible that the mutation changes the spike in some way that helps the virus evade the immune system, said Montefiori, who has worked on an HIV vaccine for 30 years. “It is hypothetical. We are looking at it very hard.”



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[uls]

Scientists say a now-dominant strain of the coronavirus appears to be more contagious than original

earlier in the epidemic sarscov2 R0 number was said to be around 2.5

in April los alamos scientists say the R0 number of sarscov2 is 5.7

that's super contagious

it's higher than common cold and flu

[Monseratto]

Sa Kyusi...

[uls]

you don't have to be a first world government with the brightest minds to get the epidemic in your country under control

this isn't quantum physics

[dr. d]

you don't have to be a first world government with the brightest minds to get the epidemic in your country under control

this isn't quantum physics

quantum physics is easier.
dun kasi, they follow the rules.
heh heh.