Shorter quarantine period for vaccinated travelers from abroad daw sabi ng DOT
Sent from my iPhone using Tapatalk
next gen vaccines -- beyond the spike
A Better COVID-19 Vaccine Could Be Less Spike-Centric - The Atlantic
spike = MVP
but mutations at the spike will eventually make 1st gen vaccines obsoleteIn the race to build the world’s first round of coronavirus vaccines, the spike protein—the thorny knobs that adorn each of the pathogen’s particles—was our MVP. Spike is a key ingredient in virtually every one of our current pandemic-fighting shots; it has been repeatedly billed as essential for tickling out any immune response worth its salt. “People put all their eggs in the spike basket,” Juliet Morrison, a virologist at UC Riverside, told me. And it undoubtedly paid off.
you can keep making boosters for specific variants but the virus can mutate faster than pharma can make vaccinesIn recent months, though, it’s become clear that the coronavirus is a slippery, shape-shifting foe—and spike appears to be one of its most malleable traits. Eventually, our first generation of spike-centric vaccines will likely become obsolete. To get ahead of that inevitability, several companies are already looking to develop new vaccine formulations packed with additional bits of the coronavirus, ushering in an end to our monogamous affair with spike. The potential perks of this tactic run the gamut: More vaccine ingredients could help the body identify more targets to attack, and loop in untapped reservoirs of immune cells that have no interest in spike. Multifaceted shots also up the ante for the virus, which can alter only so many aspects of its anatomy at once. “It’s like diversifying a portfolio,” William Matchett, a vaccinologist at the University of Minnesota who’s researching reformulated COVID-19 vaccines, told me.
di pwede spike lang
so why not whole dead virus?None of our current vaccines has yet been completely nullified by a coronavirus variant, and vaccine makers such as Moderna and Pfizer are planning to cook up additional shots containing tweaked, variant-conscious versions of spike. The problem is, strategies like these could quickly lock us into a woefully mismatched fencing bout: Microbes mutate much faster than humans invent vaccines, and with every new thrust, we’ll have time only to parry in return. When spike operates alone, it creates an obvious immunological loophole through which a virus might slip.
harder to make, mixed results
use more targetsThere’s another solution. We could simply give the immune system more hunks of the virus to target. Several vaccines containing whole coronavirus particles—which have been chemically incapacitated so they can’t cause true infections—have already been authorized, including a couple made by the Chinese company Sinopharm. Whole-virus vaccines, however, can be a pain to produce, and have delivered mixed results in the past.
like the virus' nucleocapsid and open reading frame (ORF)
Several companies, including the California-based Gritstone Bio, have decided to take a more targeted tack, selecting a subset of coronavirus traits to package into some of their repertoire of inoculations. One of Gritstone’s vaccines, which is currently in human trials, contains not only spike but also chunks of two proteins that the coronavirus keeps in its interior: one called nucleocapsid, which helps the pathogen package its genetic material, and another called ORF3a, which helps newly formed coronavirus particles mosey out of cells.
oo nga naman
rt-pcr tests look for more than 1 protein
why not apply that to vaccines?
why only show the spike to our immune system?
why not show 1 or 2 more parts of the virus?
3 more COVID-19 vaccine developers apply for clinical trials in Philippines | Philstar.com
Pero its 2 chinese vaccines and 1 korean vaccine.Reuters reported the vaccine deveoped by West China Hospital and Sichuan University uses coronavirus protein produced in insect cells to trigger immune response, while the jab made by Shenzhen Kangtai Biological Products Co. utilizes inactivated coronavirus that cannot replicate in human cells. The one developed by Eubiologics Co. Ltd. is a protein subunit vaccine.
As usual Muslim countries are not favorable with uncle sam, except Indonesia
We are in the same company with Israel, South Korea, Poland, Japan etc, unusual is Vietnam after the war between them.
Europeans are timid in liking US, they think they are on the same level and capability, except Poland and Ukraine which is not on the list which are grateful to US.
All Chinese vaccines will not be recognized
EU welcome to vaccinated Americans doesn'''t extend to travelers with Chinese jabs | Fortune
Sent from my iPad using Tapatalk
That's what makes the big difference, yung dead end host na mga naka mRNA. That's how we are supposed to end the pandemic talaga. I'd pay money to get Moderna or Pfizer legally pero wala naman access. Ang hirap lang kasi vaccinated na kami lahat sa bahay ng sinovac and yet we still continue to wear masks AT HOME and social distance. Nagsasawa na din ako kaka alcohol ng lahat ng grocery at ang bilis mabulok ng fruits and veggies namin from washing (maybe I could stop that a month after our 2nd vax) Its been more than a year since I hugged my family members. Swerte ng mga naka mRNA at ng mga tao sa paligid nila at hindi na sila contagious.
Another problem is will the government vaccinate AGAIN after 6 mos those who got Sinovac?
You can probably change some of those habits. We have stopped spraying our groceries & vegetables even before we got vaxxed but we still do spray deliveries that changed hands recently, like Lazada/shopee goods or the water jugs. Try to be more sensible in your habits lest you become a hypochondriac in time.
Sent from my iPad using Tapatalk
My Mom calls me a hypochondriac even before the pandemic so you could just imagine my protocols at the height of the pandemicSa shopee/lazada I still spray but not so much kasi patay na virus dun sa init. Yung item sa loob sometimes I do, sometimes I don't spray kasi nga patay na virus na init and I have a table in the garage where I park my purchases for a few days.
My fear when it comes to groceries and fruits/veggies baka may umubo there before I picked it up. Naiinis na nga mga tao sakin sa bahay kasi ang bilis mabulok from my washing produce, so now I stopped it na and just let it air out for 2 days, pero nabubulok pa rin sa init naman![]()
Kami hindi. They all go straight to the crisper & gets washed before being used. We don’t wear masks at home, even with my super senior mom or my 13 y/o daughter although I avoid kissing her since I am always out of the house.
Have you read of anyone contracting covid from groceries? I think it’s more of hand hygiene & avoiding touching your eyes & nose practice that’s important.
Sent from my iPad using Tapatalk
Ano ba ginagamit na vaccine sa China? Kumusta ang numbers nila doon?
Sent from my iPhone using Tapatalk
If only pwede makapunta sa HK at magpaturok dun...
HK Could Dispose Millions Of Unused Vaccine Doses | The ASEAN Post
Hong Kong is one of the few places in the world fortunate enough to have secured more than enough doses to inoculate its entire population of 7.5 million people.
But swirling distrust of the government as it stamps out dissent – combined with online misinformation and a lack of urgency in the comparatively virus-free city – has led to entrenched vaccine hesitancy and a dismal inoculation drive.
On Tuesday a member of the government's vaccine task force warned that Hong Kongers "only have a three-month window" before the city's first batch of Pfizer-BioNTech vaccines go out of date.
"The vaccines all have expiry dates," Thomas Tsang, a former controller of the Centre for Health Protection, told RTHK radio.
"They cannot be used after the expiry date and the community vaccination centres for BioNTech will, according to present plans, cease operating after September."
Tsang said it was "just not right" that Hong Kong was sitting on an unused pile of doses while the rest of the world "is scrambling for vaccines".