China Corona Virus Outbreak

[dr. d]

CORBEVAX, a new patent-free COVID-19 vaccine, could be a pandemic game changer globally

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i hope so.

we can read about the salient features of this vaccine, comparing its mode of action against that of the first vaccines,
but the truth of the matter is,
only time will tell.

[bloowolf]

i hope so.

we can read about the salient features of this vaccine, comparing its mode of action against that of the first vaccines,
but the truth of the matter is,
only time will tell.

Very similar to Novavax. While Novavax uses spike proteins cultured in moth cells, this uses the spike cultured in yeast cells. I just hope the spike can be updated.


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[uls]

protein subunit vax same as novavax

introduces the spike directly instead of instructing the body to produce the spike

[uls]

Very similar to Novavax. While Novavax uses spike proteins cultured in moth cells, this uses the spike cultured in yeast cells. I just hope the spike can be updated.


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yeah what's the use if they use old spike

antibodies produced will barely recognize omicron

[bloowolf]

yeah what's the use if they use the old spike

the antibodies produced will barely recognize omicron

Vax are normally updated based on prevailing conditions of its ability to protect against other variants. I have a feeling this vax is way well into production & packing hence the need to move it to the needy (like Africa). But as I recall, Moderna or Pfizer ba yun that is producing a more updated one.


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[dr. d]

Very similar to Novavax. While Novavax uses spike proteins cultured in moth cells, this uses the spike cultured in yeast cells. I just hope the spike can be updated.


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one feature that vaccine manufacturers are now working on,
is the ability of the manufacturer to easily replace or exchange the older antigens with updated ones, and still manufacture them faster and in bigger amounts.

[bloowolf]

one feature that vaccine manufacturers are now working on,
is the ability of the manufacturer to easily replace or exchange the older antigens with updated ones, and still manufacture them faster and in bigger amounts.

Parang motor oil manufacturing din pala. Base oils nilalagyan nang additive package[emoji16]

Kidding aside. I heard mRNAs are a lot easier to produce than conventional vax like this. Culturing the protein takes time & production will be dependent on how much the facility can handle. I have a friend who was able to visit a Pfizer facility making regular vax. They have vats holding a few million doses in sub zero temps.


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[dr. d]

Parang motor oil manufacturing din pala. Base oils nilalagyan nang additive package[emoji16]

Kidding aside. I heard mRNAs are a lot easier to produce than conventional vax like this. Culturing the protein takes time & production will be dependent on how much the facility can handle. I have a friend who was able to visit a Pfizer facility making regular vax. They have vats holding a few million doses in sub zero temps.


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yup.
design a delivery vehicle,
just replace the antigen molecule that attaches to it,
and one can easily manufacture specific vaccines easily.

i vaguely recall an early article at the start of the covid season,
the scientists were working on coronavirus, as a possible tool in the manufacture of vaccines,
when "it got away",
thus the start of the covid age.

[uls]

one feature that vaccine manufacturers are now working on,
is the ability of the manufacturer to easily replace or exchange the older antigens with updated ones, and still manufacture them faster and in bigger amounts.

that's what mRNA tech allows

all they need is the gene sequence of omicron's spike

translate it into mRNA and come up with a working vaccine in weeks

[uls]

mas mabagal / mas delikado mag produce ng traditional vax

you need the actual virus, grow the virus, inactivate/kill it etc

[uls]

But as I recall, Moderna or Pfizer ba yun that is producing a more updated one.


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sigurado they're already working on it

[bloowolf]

mas mabagal / mas delikado mag produce ng traditional vax

you need the actual virus, grow the virus, inactivate/kill it etc

With Omicron, with its less than virulent nature compared to Delta & the others, it might be possible to create an attenuated or weakened modified live virus (MLV) which in practice gives a better immune response than the killed ones. Not now but maybe in time, we’ll see that.


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[dr. d]

sigurado they're already working on it

the trick is to look for an antigenic site that doesn't change, and stimulates the immune system longer.
that way, the vaccine will work on any and all variants of the virus, even future ones, and remain effective for longer periods of time..

[uls]

the trick is to look for an antigenic site that doesn't change, and stimulates the immune system longer.
that way, the vaccine will work on any and all variants of the virus, even future ones, and remain effective for longer periods of time..

they should include the nucleocapsid

a vax that combines spike + nucleocapsid

[dr. d]

they should include the nucleocapsid

a vax that combines spike + nucleocapsid

elucidate.

[uls]

elucidate.

the nucleocapsid doesn't change as much as the spike

Abstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused the global pandemic of the Coronavirus disease in late 2019 (COVID-19). Vaccine development efforts have predominantly been aimed at 'Extra-viral' Spike (S) protein as vaccine vehicles, but there are concerns regarding ‘viral immune escape’ since multiple mutations may enable the mutated virus strains to escape from immunity against S protein. The ‘Intra-viral’ Nucleocapsid (N-protein) is relatively conserved among mutant strains of coronaviruses during spread and evolution. Herein, we demonstrate novel vaccine candidates against SARS-CoV-2 by using the whole conserved N-protein or its fragment/peptides. Using ELISA assay, we showed that high titers of specific anti-N antibodies (IgG, IgG1, IgG2a, IgM) were maintained for a reasonably long duration (> 5 months), suggesting that N-protein is an excellent immunogen to stimulate host immune system and robust B-cell activation. We synthesized three peptides located at the conserved regions of N-protein among CoVs. One peptide showed as a good immunogen for vaccination as well. Cytokine arrays on post-vaccination mouse sera showed progressive up-regulation of various cytokines such as IFN-γ and CCL5, suggesting that TH1 associated responses are also stimulated. Furthermore, vaccinated mice exhibited an elevated memory T cells population. Here, we propose an unconventional vaccine strategy targeting the conserved N-protein as an alternative vaccine target for coronaviruses. Moreover, we generated a mouse monoclonal antibody specifically against an epitope shared between SARS-CoV and SARS-CoV-2, and we are currently developing the First-in-Class humanized anti-N-protein antibody to potentially treat patients infected by various CoVs in the future.

[Monseratto]

More BA.2 from PH

VOCs detected by JPN airport screening for select Asian countries by date of arrival.

[uls]

More BA.2 from PH

nakakapagtaka ung PH genome center / DOH don't mention BA2 sublineage mga ormicron natin

[Monseratto]

Nalusaw na si Delta...

[dr. d]

nakakapagtaka ung PH genome center / DOH don't mention BA2 sublineage mga ormicron natin

baka natuto nah.
less info released, less media hype.