China Corona Virus Outbreak

[shadow]

DEFINE_ME

Need uls. Paki explain ito


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[uls]

DEFINE_ME

Need uls. Paki explain ito


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Background
A new variant of SARS-CoV-2, B.1.1.7, emerged as the dominant cause of COVID-19 disease in the UK from November, 2020. We report a post-hoc analysis of the efficacy of the adenoviral vector vaccine, ChAdOx1 nCoV-19 (AZD1222), against this variant.

^^^
they wanted to see if Astrazeneca vaccine is effective against UK variant (B117)

they looked at previous data (post hoc)

Methods
Volunteers (aged ≥18 years) who were enrolled in phase 2/3 vaccine efficacy studies in the UK, and who were randomly assigned (1:1) to receive ChAdOx1 nCoV-19 or a meningococcal conjugate control (MenACWY) vaccine, provided upper airway swabs on a weekly basis and also if they developed symptoms of COVID-19 disease (a cough, a fever of 37·8°C or higher, shortness of breath, anosmia, or ageusia). Swabs were tested by nucleic acid amplification test (NAAT) for SARS-CoV-2 and positive samples were sequenced through the COVID-19 Genomics UK consortium. Neutralising antibody responses were measured using a live-virus microneutralisation assay against the B.1.1.7 lineage and a canonical non-B.1.1.7 lineage (Victoria). The efficacy analysis included symptomatic COVID-19 in seronegative participants with a NAAT positive swab more than 14 days after a second dose of vaccine. Participants were analysed according to vaccine received. Vaccine efficacy was calculated as 1 − relative risk (ChAdOx1 nCoV-19 vs MenACWY groups) derived from a robust Poisson regression model. This study is continuing and is registered with ClinicalTrials.gov, NCT04400838, and ISRCTN, 15281137.

^^^
this was phase 2/3 trial

they gave AZ vaccine or control vaccine to volunteers and monitored them

Findings
Participants in efficacy cohorts were recruited between May 31 and Nov 13, 2020, and received booster doses between Aug 3 and Dec 30, 2020. Of 8534 participants in the primary efficacy cohort, 6636 (78%) were aged 18–55 years and 5065 (59%) were female. Between Oct 1, 2020, and Jan 14, 2021, 520 participants developed SARS-CoV-2 infection. 1466 NAAT positive nose and throat swabs were collected from these participants during the trial. Of these, 401 swabs from 311 participants were successfully sequenced. Laboratory virus neutralisation activity by vaccine-induced antibodies was lower against the B.1.1.7 variant than against the Victoria lineage (geometric mean ratio 8·9, 95% CI 7·2–11·0). Clinical vaccine efficacy against symptomatic NAAT positive infection was 70·4% (95% CI 43·6–84·5) for B.1.1.7 and 81·5% (67·9–89·4) for non-B.1.1.7 lineages.

^^^
says there was lower neutralization activity against UK variant (B117) compared to non-B117 (Victoria)

says the vaccine is 70.4% effective in preventing symptoms (B117), 81.5% effective in preventing symptoms (non-B117)

Interpretation
ChAdOx1 nCoV-19 showed reduced neutralisation activity against the B.1.1.7 variant compared with a non-B.1.1.7 variant in vitro, but the vaccine showed efficacy against the B.1.1.7 variant of SARS-CoV-2.

^^^
eventhough the vaccine has lower efficacy against UK variant, it still works

[shadow]

So effective pa rin astra ang sinovac ba meron study na kung effective sa new variants?


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[uls]

So effective pa rin astra ang sinovac ba meron study na kung effective sa new variants?


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di ko alam eh

tsaka ung UK study that's only for UK variant

UK variant doesn't have the dreaded E484K mutation unlike South Africa, Brazil, PH variant

remember AZ vaccine was almost useless against South Africa variant kaya hininto nila ang pag gamit doon

[ray_noel]

Mouth wash...


Research suggests toothpaste and mouthwash ingredients could help prevent SARS-CoV-2 infection-Mar 24 2021



Toothpaste and mouthwash inactivate 99.9% of the virus that causes COVID-19 | British Dental Journal



Mouthwash could reduce COVID-19 transmission: Study | Arab News

Sa ilong kaya merong kayang parang moutwash na we can spray para mapatay din yung mga virus...


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[uls]

sana minomonitor ng DOH mga nabakunahan (whether sinovac or astra)

para malaman if those vaccines can prevent severe symptoms

huwag masyado mataas expectation

sigurado mahahawaan parin -- mag popositibo sa swab

ang importante kung ma-prevent ang severe symptoms

[Wh1stl3r]

Sa ilong kaya merong kayang parang moutwash na we can spray para mapatay din yung mga virus...


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'Life-saving' nose spray that kills 99.9% of viruses begins production in Israel | The Times of Israel

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[H1Tman]

A certain Dr. Landrito is making his own and giving Ivermectin to covid patients. Without permit.


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[ale828]

Ang bilis ng manila mag roll out ng vaccines. Bukas start na ng mga meron comorbidities 18-59 yrs old.


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Galing ni Isko ha

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AFAIK the roll out for manila vaccine for people with comorbidities is galing national Government (DOH).
they will be using Sinovac vaccine. kaya 18-59yrs old ang for vaccination na classified as A4. rather than Seniors with comorbidities classifies as A2 and A3 which should get the vaccine first.
Wala pa rin kasi dumadating na Astrazeneca na inorder ni Isko. Pero alam ko Manila will be the first to get Astrazeneca vaccine when it arrives.

\ Lagi naman ako naka mask and face shield, pero kapag kumakain na yun na.. open space naman mga kinakainan ko, so di ko alam kung natsambahan talaga ako..

Ma'am Open space as in outdoor? or large food court which is still considered indoor air is still circulating within.
kahit outdoor dinning kasi you can still get infected if you have someone near you which is asymptomatic and releasing the virus.

Sadly your experience is the same thing happening to a lot of people in the phil and also the reason before we can't seem to lower the number of cases before. takot yung iba na mahiwalay sa mga pamilya nila. Takot mag pa test.
The source of the infection is most likely the time spent with your friends, one of them might be asymptomatic. We tend to be lax with our safety protocol when we are with friends and family. thou pwede rin the time you ate, practically any time you take off your mask you increase the chances of getting infected by several folds.

[shadow]

A certain Dr. Landrito is making his own and giving Ivermectin to covid patients. Without permit.


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As usual inutil FDA. Sinabi niya mismo harap-harapan sa kanila. Wala pa rin ginagawa.


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[Flipo]

61 year old dad... Hospitals are full.

The hospital association president Dr. Jaime Almora in a DZBB radio interview was telling, natalo na tayo.
Ang problema daw ay di yung hospital bed, kung di yung personnel (nurse) na konti na lang at pagod na.

The Philippine Hospital Association is asking the Department of Health to request government agencies to lend their nurses who are currently not doing health-related work, to help address the rising number of COVID-19 cases.

"Since there is an acute need, we really have to borrow personnel," said the association's president Dr. Jaime Almora in an interview with CNN Philippines' News.PH on Thursday.

[Deestone]

Saw in some post that lianhua chinese med is readily available in mercury.... but not sure if need doctors prescription.

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[misseksaherada]

Ma'am Open space as in outdoor? or large food court which is still considered indoor air is still circulating within.
kahit outdoor dinning kasi you can still get infected if you have someone near you which is asymptomatic and releasing the virus.

Sadly your experience is the same thing happening to a lot of people in the phil and also the reason before we can't seem to lower the number of cases before. takot yung iba na mahiwalay sa mga pamilya nila. Takot mag pa test.
The source of the infection is most likely the time spent with your friends, one of them might be asymptomatic. We tend to be lax with our safety protocol when we are with friends and family. thou pwede rin the time you ate, practically any time you take off your mask you increase the chances of getting infected by several folds.

Open space outdoor po.. Tuwing kakain yun talaga, inaalis ko talaga mask and face shield.. Kahit sa loob ng sasakyan naka-mask kami..
Isa po ako sa case na hindi counted sa statistics ng COVID positive.. Contributor sa pasaway na nagta travel kahit hindi naman essential ang gagawin.. hindi po ako proud, shini share ko lang din para wala na tunulad pa..

[Papajamba]

feeling ko hindi ako feb 14 nahawa kung may incubation period pa yung virus.. somewhere in between dun sa feb 6 to 14..
nag share lang din ako para hindi ako tularan, huwag maging kampante..
Mild lang masasabi ko yung tumama sakin, kinaya ko pa mag work.. Sa 3rd week dun na ako nag 2 days leave.. And buti na lang yung breathing ko hindi apektado..

Pwede ka magpatest called covid ECLIA antibody test para malaman if may antibodies ka na against covid.
If may value lumabas sa IgG, nagkacovid ka at may antibodies ka na.
If negative, either hindi ka nagka-covid or hindi gumawa ng antibodies ang immune system mo.

sana minomonitor ng DOH mga nabakunahan (whether sinovac or astra)

para malaman if those vaccines can prevent severe symptoms

huwag masyado mataas expectation

sigurado mahahawaan parin -- mag popositibo sa swab

ang importante kung ma-prevent ang severe symptoms

Yes, may daily logbook via QR/google form na fill-up ng hcw after ng vaccine up to 1 year post-vaccine. Para alam nila side effects and ano nangyari sa hcw.

As usual inutil FDA. Sinabi niya mismo harap-harapan sa kanila. Wala pa rin ginagawa.

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Narinig ko na nag-raid ang FDA sa warehouse ni Dr Landrito kung saan sya nagrerepack ng ivermectin nya.

A doctor friend just posted na may patient na naging severe inspite of taking ivermectin, kaya he’s against its use at nadedelay lang proper treatment.


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[shadow]

AFAIK the roll out for manila vaccine for people with comorbidities is galing national Government (DOH).
they will be using Sinovac vaccine. kaya 18-59yrs old ang for vaccination na classified as A4. rather than Seniors with comorbidities classifies as A2 and A3 which should get the vaccine first.
Wala pa rin kasi dumadating na Astrazeneca na inorder ni Isko. Pero alam ko Manila will be the first to get Astrazeneca vaccine when it arrives.



Ma'am Open space as in outdoor? or large food court which is still considered indoor air is still circulating within.
kahit outdoor dinning kasi you can still get infected if you have someone near you which is asymptomatic and releasing the virus.

Sadly your experience is the same thing happening to a lot of people in the phil and also the reason before we can't seem to lower the number of cases before. takot yung iba na mahiwalay sa mga pamilya nila. Takot mag pa test.
The source of the infection is most likely the time spent with your friends, one of them might be asymptomatic. We tend to be lax with our safety protocol when we are with friends and family. thou pwede rin the time you ate, practically any time you take off your mask you increase the chances of getting infected by several folds.

Naumpisahan na rin nila seniors then sinabay na nga itong mga 18-59 with co-morbid.


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[shadow]

Pwede ka magpatest called covid ECLIA antibody test para malaman if may antibodies ka na against covid.
If may value lumabas sa IgG, nagkacovid ka at may antibodies ka na.
If negative, either hindi ka nagka-covid or hindi gumawa ng antibodies ang immune system mo.


Yes, may daily logbook via QR/google form na fill-up ng hcw after ng vaccine up to 1 year post-vaccine. Para alam nila side effects and ano nangyari sa hcw.

Narinig ko na nag-raid ang FDA sa warehouse ni Dr Landrito kung saan sya nagrerepack ng ivermectin nya.

A doctor friend just posted na may patient na naging severe inspite of taking ivermectin, kaya he’s against its use at nadedelay lang proper treatment.


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Yan doctor mismo hulihin nila.


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[Monseratto]

Sa ilong kaya merong kayang parang moutwash na we can spray para mapatay din yung mga virus...


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Meron... pero ito yung gingawa ng iba...

[Deestone]

Surprisingly in one of the latest video of doc willie ong he mentioned that he has yet to be vaccinated and he prefers J&J one shot only as compared with other vaccines.... he argued that what if the 2nd shot will not be available.

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[ray_noel]

Meron... pero ito yung gingawa ng iba...

Pero not yet proven effective againts covid-19 unlike sa mouthwash...

Sana yung parang vicks inhaler yung againts covid-19 para sa ilong... tapos mouthwash...

Parang home remedies... then gawin araw2...


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[glenn_duke]

Pero not yet proven effective againts covid-19 unlike sa mouthwash...

Sana yung parang vicks inhaler yung againts covid-19 para sa ilong... tapos mouthwash...

Parang home remedies... then gawin araw2...


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Betadine oral and nasal spray gamit ko.