China Corona Virus Outbreak

[uls]

sa mRNA vaccines naman they use tiny bubbles of fat as delivery vehicle (lipid nanoparticles)

those are absorbed by our cells

pag na-absorb na, the mRNA is released inside the cells

[Monseratto]

BREAKING: Metro Manila mayors agree to impose unified curfew hours in the capital region from 8pm to 5am starting tomorrow, April 12, until the end of MECQ on April 30.

[uls]

Actually, you guys know more about these vaccines than most doctors I know. Mga doktor na kilala ko, pag tinatanong namin, they just give a short explanation or say “basta importante mabakunahan” [emoji6]
But, I think these things will matter most when we have the luxury to choose (&pay for it) in the future.


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they're too busy

as for me i got a lot of time to read and i'm naturally curious

[uls]

from what i understand,
the advantage of these nucleic acid-based vaccines,
is the relative ease of manufacturing large amounts of vaccine in a shorter period of time, compared to the traditional vaccine-making methods employing larger virus structures.

while the specific molecular mechanisms of how the vaccine works is known,
the predicted intensity, effectiveness, and universality of their action,
remains to be seen.

yes it takes more time and work to make inactivated vaccines coz you have to grow the viruses in large tanks

pag genetic instructions lang mas madali

[bloowolf]

they're too busy

as for me i got a lot of time to read and i'm naturally curious

Precisely. & most doctors I know just depend on the feedback within the medical community as to what vaccine to use & what is available. That’s why never ask a doctor about the technicalities of the different vaccines because, they don’t know, hehe


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[uls]

guys watch this

this is a very good and fun video demonstrating how mRNA vaccines work

TikTok

[111prez]

PNP says no changes in enforcement under MECQ | Philstar.com

Salot talaga itong CHINA WUHAN VIRUS

[dr. d]

doubledouble.

[bloowolf]

but of course!
doctors DO rely on their colleagues who are the specialists in in the field.
in this case, infectious disease, immunology, geriatrics and other specialties.
no doctor is a master of all.

I edited my post doc. A common stereotype of a doctor is, they should know everything about the human body because “doctor ka, eh”.


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[dr. d]

Precisely. & most doctors I know just depend on the feedback within the medical community as to what vaccine to use & what is available. That’s why never ask a doctor about the technicalities of the different vaccines because, they don’t know, hehe


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precisely!
all doctors, bar none, rely on their colleagues who are the experts in the field, for advise.
no doctor is a master of all.
in this case, we ask our colleagues who are well-versed in infectious disease, immunology, geriatrics and other specialties.

kumbaga sa kotse,
i don't bring my car to the aircon shop for a breaks problem.

[dr. d]

I edited my post doc. A common stereotype of a doctor is, they should know everything about the human body because “doctor ka, eh”.


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unfortunately, you are correct.
laymen think all doctors are very knowledgeable in all fields of human illness.
it happens a lot, po.
i just tell them i'm a PhD in fungi.
that usually terminates the conversation.
heh heh.
joke.

[bloowolf]

This is about the Gamaleya or Sputnik vaccine. It’s a non-replicating double stranded DNA vaccine riding in an adenovirus, unlike Pfizer which directly uses the mRNA. Looks good “on paper”. Kumbaga sa kotse, ok sa brochure. Kailangan lang i-test drive.

Sputnik V is based on the virus’s genetic instructions for building the spike protein. But unlike the Pfizer-BioNTech and Moderna vaccines, which store the instructions in single-stranded RNA, Sputnik V uses double-stranded DNA.

How Gamaleya’s Sputnik V Vaccine Works - The New York Times


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[bloowolf]

unfortunately, you are correct.
laymen think all doctors are very knowledgeable in all fields of human illness.
it happens a lot, po.
i just tell them i'm a PhD in fungi.
that usually terminates the conversation.
heh heh.
joke.

If you followed Marvel’s Captain America, in a scene, Black Widow tells Cap that “I just act like I know everything Rogers”.


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[dr. d]

This is about the Gamaleya or Sputnik vaccine. It’s a non-replicating double stranded DNA vaccine riding in an adenovirus, unlike Pfizer which directly uses the mRNA. Looks good “on paper”. Kumbaga sa kotse, ok sa brochure. Kailangan lang i-test drive.

Sputnik V is based on the virus’s genetic instructions for building the spike protein. But unlike the Pfizer-BioNTech and Moderna vaccines, which store the instructions in single-stranded RNA, Sputnik V uses double-stranded DNA.

How Gamaleya’s Sputnik V Vaccine Works - The New York Times


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while many things do look good on paper,
a number may fail miserably along the way, performing below expectation.
merck...

[dr. d]

If you followed Marvel’s Captain America, in a scene, Black Widow tells Cap that “I just act like I know everything Rogers”.


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but she does know many things!
she was among the other side's best spies.

[bloowolf]

while many things do look good on paper,
a number may fail miserably along the way, performing below expectation.
merck...

Correct. That’s why I reserve judgement for the vaccines efficiency for the future since as more & more people get vaccinated, the efficiency stats of the vaccine start dropping. But knowing these stats is just a novelty for now. I still believe that getting vaccinated is a must & the choice is not mine now.


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[uls]

This is about the Gamaleya or Sputnik vaccine. It’s a non-replicating double stranded DNA vaccine riding in an adenovirus, unlike Pfizer which directly uses the mRNA. Looks good “on paper”. Kumbaga sa kotse, ok sa brochure. Kailangan lang i-test drive.

Sputnik V is based on the virus’s genetic instructions for building the spike protein. But unlike the Pfizer-BioNTech and Moderna vaccines, which store the instructions in single-stranded RNA, Sputnik V uses double-stranded DNA.

How Gamaleya’s Sputnik V Vaccine Works - The New York Times


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yep

Sputnik uses adenovirus #26 and #5 as delivery vehicle

contains SARSCOV2 spike DNA

1st dose -- #26 adenovirus

2nd dose -- #5 adenovirus

[dr. d]

Correct. That’s why I reserve judgement for the vaccines efficiency for the future since as more & more people get vaccinated, the efficiency stats of the vaccine start dropping. But knowing these stats is just a novelty for now. I still believe that getting vaccinated is a must & the choice is not mine now.


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sabi nga ng infectious disease expert,
"magpa-vacuna na kayo ngayon, so's it might just save your life so that you can later study and worry about the other vaccines' superiority over the one you had...".

[uls]

mautak ung nag isip niyan

coz 1st dose exposing the body to Ad26 baka magdevelop ng antibodies for that

pag 2nd dose mo Ad26 uli, baka maharang ng immune system before delivering the payload

so use another adenovirus for 2nd dose

galing

-

maybe that explains sputnik's higher efficacy kesa astra and j&j (adenoviral vector din)

[dr. d]

mautak ung nag isip niyan

coz 1st dose exposing the body to Ad26 baka magdevelop ng antibodies for that

pag 2nd dose mo Ad26 uli, baka maharang ng immune system before delivering the payload

so use another adenovirus for 2nd dose

galing

maybe they already had experimental basis for the decision...