if you say na cost is not a consideration, then you will get a million different answers because cost is the biggest factor to consider when designing a system.

the advice that i can give is if cost is not really that big a deal, try to go with a 4 way setup. this is usually comprised of a pair of tweets, a pair of midranges, a pair of midbasses, and a single or pair of subwoofers. pwedeng full active or passive and active combined. a 4 way system with a good eq and crossover will be nice

andy