Dengue thread

[madball]

so during the large scale clinical trials Sanofi can't test every single one of the millions of kids and just used age 9 as the minimum assuming that by age 9 na-infect na (in dengue prevalent countries like PH)

syempre there will be those who haven't been infected yet but Sanofi took the risk nalang

maybe they thought the numbers would be small

a few deaths can be acceptable

So there's really negligence on Sanofi's side then. Wala pang long term safety assessment, ginamit na sa mass vaccination....

[madball]

there's also the dizzying swiftness of events.. sabi nga ng isang matagal na sa gubyerno..."considering the amount of moneys involved...napaka-bilis!"

Posible na may corruption doc as Sanofi has been involved in multiple bribery cases before.

[uls]

Aquino met Sanofi officials twice

Aquino confirms Sanofi meetings but denies knowing questionable record


i'm not trying to insinuate anything

but a major pharma company seeking to sell its dengue vaccine to a 3rd world government has to talk to the country's president of course

[dr. d]

Posible na may corruption doc as Sanofi has been involved in multiple bribery cases before.

my personal belief is, "pnoy did not accept bribe money. but he may have been swayed by the ...political advantage that it was offering at that time.."
what about the lower downs? ...tricky question, that...

my thoughts are this,
one set of learned advisers says yeigh.
another set of learned advisers says neigh.
...papano nah?
in retrospect, it should have been "let's shelf it for the meantime, and wait for developments."

but i wouldn't want to be the one who would make that decision.

from an historical point of view,
the vaccine may have saved a potential half a million, at the expense of a few hundred.
but only a history or statistics book can make that cold, heartless rationalization.

[shadow]

my personal belief is, "pnoy did not accept bribe money. but he may have been swayed by the ...political advantage that it was offering at that time.."
what about the lower downs? ...tricky question, that...

my thoughts are this,
one set of learned advisers says yeigh.
another set of learned advisers says neigh.
...papano nah?
in retrospect, it should have been "let's shelf it for the meantime, and wait for developments."

but i wouldn't want to be the one who would make that decision.

from an historical point of view,
the vaccine may have saved a potential half a million, at the expense of a few hundred.
but only a history book or a statistics manual can make that cold, heartless rationalization.

Sanofi hid their tests about the adverse effects of dengvaxia. That's the bottom line.

As for pnoy meeting with them. There was an outbreak and here comes a pharmaceutical company that supposedly has the cure. If I'm in his shoes, I'll do the same thing. Meet with them and here what's this medicine that can at least prevent outbreak in the future.

But since I'm not an expert in Yoona hook sanafi to agency that's dealing with this stuff which is DOH/FDA.

Kung ang bigay na report sa akin eh ok naman dahil ginagamit na na ibang bansa bakit ko hinde papa gamit para mapigilan na yan dengue outbreak every year. That's assuming walang tinago na report ang Sanofi.

And besides ok din sa WHO. So who am I to say no?


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[dr. d]

even with all this in the past, i still find it difficult...
it's like using toxic medicine to save some lives and lose others.

[StockEngine]

almost 500 dead...

[dr. d]

almost 500 dead...

"we must weigh what we might lose, by what we might gain. - col. hessler (robert shaw), battle of the bulge.

[kisshmet]

even with all this in the past, i still find it difficult...
it's like using toxic medicine to save some lives and lose others.

Doc what do you think is the progressive way to deal with this perennial problem?

For me fumigation is regressive, it simply drive away the mosquito carrier

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[dr. d]

Doc what do you think is the progressive way to deal with this perennial problem?

For me fumigation is regressive, it simply drive away the mosquito carrier

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i do not want to be the person who has to make the decision.
it's a kobayashi maru.

seriously,
i would have used dengvaxia. but i would have followed the screening protocols.
involve the patient in the decision-making process. tell them, "the medicine may heal you, or it may kill you. these are the statistics.".
we actually do it all the time.

[kisshmet]

i do not want to be the person who has to make the decision.
it's a kobayashi maru.

seriously,
i would have used dengvaxia. but i would have followed the screening protocols.
involve the patient in the decision-making process. tell them, "the medicine may heal you, or it may kill you. these are the statistics.".
we actually do it all the time.

In that case the current admin should not have ceased the program of inoculation, they should just have followed the latest directive to have the test required no matter how expensive it is coz the vaccine was already paid for, considering there were no outbreak after the mass vaccinations implementation

The current admin should have looked for additional funding for the required pre-administration test.

They stopped it, received the refund and now we have this recurring fatal problem

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[madball]

In that case the current admin should not have ceased the program of inoculation, they should just have followed the latest directive to have the test required no matter how expensive it is coz the vaccine was already paid for, considering there were no outbreak after the mass vaccinations implementation

The current admin should have looked for additional funding for the required pre-administration test.

They stopped it, received the refund and now we have this recurring fatal problem

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I agree. We need an effective pre-vaccination screening method. I don't know if there's already an accurate diagnostic test to detect past dengue infections.

[dr. d]

In that case the current admin should not have ceased the program of inoculation, they should just have followed the latest directive to have the test required no matter how expensive it is coz the vaccine was already paid for, considering there were no outbreak after the mass vaccinations implementation

The current admin should have looked for additional funding for the required pre-administration test.

They stopped it, received the refund and now we have this recurring fatal problem

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"difficult."
wrong timing.
it was mob rule.
the victims' parents were on the warpath, fueled by well-meaning "professionals"..
authority was publicly questioning those potentially guilty, even as one's guilt was as basically ministerial as certifying that the document passed by his tabletop...
learned scientists' professional opinions were being torn to shreds by non-medical interrogators.
everyone was angry.
they were looking for someone to blame.
during those trying times, anyone who even remotely suggested the vaccine be used again, stood a good chance of getting lynched.

but later research findings indicate that the vaccine does work as advertised, if the recommended screening protocols were followed.
...have they repealed their earlier repeal of the vaccine's use?
if they haven't repealed their earlier repeal, then the vaccine won't be legally available locally.

[kagalingan]

Ito may nabasa ako article. Maganda ito ginawa ng china. Ito ang enhance advance traditional chinese medicine because they really care sa tao kasi no more inom-inom gamot. Direch na sa source ng problem by eradicating moskweetoes.

Pag western talaga and back by pharmaceuticals eh walang kamatayan na bakuna or gamot yan. Ako may pagka anti-vaccer as much as possible kung pwede waley bakuna eh avoid talaga.

Pero sa china mahlupet yung ginawa. Bina-og mga lamok. Yun nga lang they manipulated the ecosystem pero hindi naman lahat dahil sa kagubatan eh maiiwan pa din si lamok.

and dont forget to read about sugar. Its makes you secxually attractive.

Science
Chinese scientists’ new technique to wipe out mosquito populations may provide vital new weapon against range of deadly diseases

Researchers managed to eradicate populations on two islands in Guangzhou province in two years by releasing 200 million insects specially bred to be infertile

Mosquitoes carry a range of diseases such as malaria and dengue fever and scientists believe using biological technique may be best for the environment
Stephen Chen
Published: 1:00am, 18 Jul, 2019


Tiger mosquitoes help spread tropical diseases. Photo: Shutterstoc

Scientists have wiped out the entire population of mosquitoes on two islands in southern China using radical techniques to render the males infertile, according to a new study that could transform the fight against a range of deadly diseases.

Over nearly two years, scientists released more than 200 million specially bred male Asian tiger mosquitoes on Shazai and Dadaosha islands in the delta to the south of Guangzhou city, the area with the highest number of dengue fever cases in China.

The study, published in the latest edition of the journal Nature, said the mosquitoes, also known as Aedes albopictus, had been exposed to short bursts of gamma radiation and received three artificially induced infections from three different species of Wolbachia, a parasitic microorganism, to make them infertile.

The males were also fed with sugar in the hope of making them bigger and stronger – and therefore more attractive to female mosquitoes during the mating season.

This, combined with the sheer weight of numbers of the infertile mosquitoes, was intended to tip the evolutionary balance by ensuring that the females’ eggs – if any were laid at all – would not hatch.

By the end of the two-year experiment, the native mosquito populations on the islands had vanished completely.

The scientists did find a few individual mosquitoes still living on the islands in Guangdong province, but genetic analysis suggested their origins lay elsewhere and they had probably been carried there by cars or by ships.

Although Asian tiger mosquitoes – so named because of their distinctive white stripes – can transmit a range of diseases, including the Zika and West Nile viruses as well as dengue fever, a lot of locals were initially sceptical about the project.

The research was led by Professor Xi Zhiyong from the Sun Yat-sen University-Michigan State University Joint

Centre of Vector Control for Tropical Diseases, with official support from the Guangzhou Centre for Disease Control and Prevention.

The study said that in the beginning, only 13 per cent of the people on Shazai island had supported the work.

The researchers had released more than 140 million of the insects on the 3 sq km (1.9 square mile) island – which equated to 72,000 mosquitoes for every one of its 2,000 or so residents – and even thought the males do not bite, many locals felt uncomfortable about having so many released into their neighbourhood.

But by the end of the experiment, opinion polls showed that almost all the locals supported – or at least did not oppose – the project after the number of bites recorded fell by more than 96 per cent.


The mosquitoes were fed sugar but also infected with parasitic viruses. Photo: AFP

“In the past there were so many mosquitoes we dared not stay outside in late afternoon. Now mosquitoes can barely be seen and those few remaining rarely bite,” a Shazai restaurant owner surnamed Li said in a phone interview on Wednesday.

“The technology is a miracle. We used to be sceptics. Now we are fans.”

The government-run mosquito-breeding facility in Guangzhou province can produce 10 million modified males a week, but the ecological impact of this and other similar projects poses a potential dilemma for scientists

Mosquito larvae is an important source of food for fish while the fully grown insects also serve as prey for birds.

But a survey conducted by Nature in 2010 suggested that most biologists would prefer to see mosquitoes wiped off the Earth because they carried a lot of deadly diseases.

Mosquitoes kill more than 700,000 people around the globe each year, according to some studies, which makes them the most deadly creatures of all for humans.

Mosquito-borne diseases include malaria, dengue and yellow fever, Japanese encephalitis and the Zika virus, which has spread in recent years and is linked to a range of birth defects.

But Professor Ge Feng, director of the state laboratory of integrated management of insect and rodent pests at the Chinese Academy of Sciences in Beijing, said he fully supported the Guangzhou study.

“Mosquitoes have no place in human-populated areas. The harm they do far exceeds the benefits to the ecological system,” Ge said.

The artificially bred mosquitoes will only have an impact in limited areas, and the insects will continue to thrive in the wild, he said.

He Jinsheng, a professor of ecology at Peking University, said the gap in the food chain caused by breeding-suppression techniques would “quickly, easily be filled by other, non-biting insects” and “the negative impact will be minimal”.

He argued that compared with other mosquito control methods such as the use of chemical pesticides and insect repellents, the biological approach from the Guangzhou project might be the least harmful to the environment.

This article appeared in the South China Morning Post print edition as: Engineered mosquitoes kill whole population in study

Chinese scientists’ new technique to wipe out mosquito populations may provide vital new weapon against range of deadly diseases | South China Morning Post

[Yatta]

Ito may nabasa ako article. Maganda ito ginawa ng china. Ito ang enhance advance traditional chinese medicine because they really care sa tao kasi no more inom-inom gamot. Direch na sa source ng problem by eradicating moskweetoes.

Pag western talaga and back by pharmaceuticals eh walang kamatayan na bakuna or gamot yan. Ako may pagka anti-vaccer as much as possible kung pwede waley bakuna eh avoid talaga.

Pero sa china mahlupet yung ginawa. Bina-og mga lamok. Yun nga lang they manipulated the ecosystem pero hindi naman lahat dahil sa kagubatan eh maiiwan pa din si lamok.

and dont forget to read about sugar. Its makes you secxually attractive.




Chinese scientists’ new technique to wipe out mosquito populations may provide vital new weapon against range of deadly diseases | South China Morning Post

2010 pa ginagawa na ng PNRI yan.

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[dr. d]

2010 pa ginagawa na ng PNRI yan.

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yespo.
the technology isn't anywhere near new.
but it takes a certain amount of... dedication... to do it.

[StockEngine]

2000%

[kagalingan]

yatty and doki,

kaya kulang sa dedication baka kinontra ng pharmaceutical. Kung wipe-out ang lamok paano si dengoyvaxia and kita ng hospital sa emergency ward.

to philippine government, doh, fda. Talk to china about this. Hello???

[dr. d]

yatty and doki,

kaya kulang sa dedication baka kinontra ng pharmaceutical. Kung wipe-out ang lamok paano si dengoyvaxia and kita ng hospital sa emergency ward.
?

...you honestly believe what you're saying...?

[sirkosero]

...you honestly believe what you're saying...?

That is the resident troll. He will do anything to try to be significant.

Relax lang doc. Tagal na din tayo dito

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