My family is used to such drives thankfully; my youngest still prefers using the child car seat as it has good lumbar support while my elder child knows well enough to take some motion meds and eat light to keep nausea in check.
Right now we usually choose to spend one day going around then one day lounging around which is why getting a good resort or hotel is always a priority even if it costs more. Ten years ago when we were just about starting off, we'd find the cheapest and most fun accommodations then hack it out anywhere. Age
My pickup ride gets rough on poorly cemented roads though (not bouncy... but you get rattled).