Dengue Vaccine by 2016

[StockEngine]

Sanofi a French pharmaceutical company has acquired approval in Mexico and pending approval in India for "dengvaxia"

Sanofi gets first approval for dengue vaccine - PMLiVE

Hope we get this soon..

[pyramid00]

Sanofi a French pharmaceutical company has acquired approval in Mexico and pending approval in India for "dengvaxia"

Sanofi gets first approval for dengue vaccine - PMLiVE

Hope we get this soon..

Speaking about dengue, i once heard on 'mabeauty po naman' hosted by ms cory quirino that they had tried a zapper device on a patient in a cagayan hospital that the patient's platelets was so low (50k). After using the electrical device, the patient recovered after 24 hours. Same device was used at the veterans regional hospital and a patient recovered. I wrote to the heads of these two hospitals and they were silent about it. (nginig b silang dalawa).

May alternative healing methods na rin sa VRH but the use of electrical devices using microcurrents is still not used as of this writing. The theory given is that the small amount of electrical current will kill the pathogens in the blood. At first, i found this healing method very funny, however I have read that these technique is used in some hospitals in the US. There is an american patent that use micro currents for healing. I also found out that there is a filipino who cured himself and his son of hiv/hepa.

There is a new terrible disease that affects newborn babies to be deformed because their mothers had the disease during pregnancy. The medical entities had advised mothers to delay pregnancy for two years; by that time a new cure will be available. Wow! kwarta na naman 'to, tol. In some US hospitals and esp in europe, ucurrents is being used with success. Walang side effects kung hindi magagamot ang pasyente. In fact, there are patents in the US that use ucurrents for healing. Syempre, di pa alam ng mga ganid na taong ito with warped dna's. sorry, a spade is a spade.

[StockEngine]

2017 April pala

SONA: Pangamba ng ilang doktor, 'di pa tiyak kung ligtas ang libreng dengue vaccine - YouTube

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[badkuk]

^ i'm not too sure about being the test subjects of a new vaccine, but on the other hand, dengue does pose a more imminent threat.

[StockEngine]

Bro..I spent way too much helping dengue patients hehehe.

Any hope is good

When theyre spitting blood...its just tough

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[uls]

Did some reading of scientific publications before commenting on this hot issue

Turns out dengue experts have known for a long time that a 2nd dengue infection is more severe than the first

In the 1st infection you only get flu-like symptoms

If you get infected again but with another strain (there are 4 dengue strains), your body could overreact causing dengue hemorrhagic fever / dengue shock syndrome

Kaya pala sabi they shouldn't have given vaccine to those who have never gotten dengue

Coz the vaccine acts like the first infection

[uls]

Since hindsight is 20/20

They should have tested those kids first kung meron dengue antibodies

They should not have given the vaccine to those without antibodies

Well Sanofi can argue they only gave the vaccine to those 9 yrs and older. By the time a kid reaches 9 it's more likely he/she has already been exposed to dengue

But age is no guarantee that a kid has already been exposed to dengue

The damage is done

Nobody knows how many of those 700,000 plus kids are dengue-naive

Obserbahan nalang ng mga magulang anak nila

[kagalingan]

kailangan talaga magka-open space park for every 4kilometer sa city....

ito yung resbak ng mga lamok...... puro cemento na.....

we are a tropical country.... we need to maintain identity ng pinas..... bakit pa condo-condo.... pa mall-mall......

for me the best is to harmonize with the lamok.... give them their space.....

wala ng mini-forest sa metro manila...

[Flipo]

Since hindsight is 20/20

They should have tested those kids first kung meron dengue antibodies

They should not have given the vaccine to those without antibodies

Well Sanofi can argue they only gave the vaccine to those 9 yrs and older. By the time a kid reaches 9 it's more likely he/she has already been exposed to dengue

But age is no guarantee that a kid has already been exposed to dengue

The damage is done

Nobody knows how many of those 700,000 plus kids are dengue-naive

Obserbahan nalang ng mga magulang anak nila

While Sanofi has been compliant and rational in its disclosure, it is regrettable that the only thing the local media has focused on are statements of the “I told you so” brigade who were opposed to the vaccinations on differing grounds. In hindsight, they are now proven “right,” but why in the first place did they not convince government or Congress to stop the drug from being used? They failed because they fought their battle in the field of politics and press release or media interviews, instead of science and professionalism. Some had agendas in government, others were promoting their lifestyle beliefs and as a result the real arguments against the dengue vaccine got polluted or diluted. Unfortunately even the politicians who were indifferent then are now charging into the fray like righteous warriors. Some one should hand them each a sash with the motto: “So Ignorant yet So Arrogant.”


‘The sky is falling’ | Opinion, News, The Philippine Star | philstar.com

[maxpedition]

While Sanofi has been compliant and rational in its disclosure, it is regrettable that the only thing the local media has focused on are statements of the “I told you so” brigade who were opposed to the vaccinations on differing grounds. In hindsight, they are now proven “right,” but why in the first place did they not convince government or Congress to stop the drug from being used? They failed because they fought their battle in the field of politics and press release or media interviews, instead of science and professionalism. Some had agendas in government, others were promoting their lifestyle beliefs and as a result the real arguments against the dengue vaccine got polluted or diluted. Unfortunately even the politicians who were indifferent then are now charging into the fray like righteous warriors. Some one should hand them each a sash with the motto: “So Ignorant yet So Arrogant.”


‘The sky is falling’ | Opinion, News, The Philippine Star | philstar.com

someone really earn a lot on this[emoji35] in exchange for many innocent people[emoji43] nasaan kunsensya nyo[emoji36]

[Flipo]

Ms Garin is now an adviser of Speaker Pantaleon Alvarez, and has, in an effort to escape responsibility, laid the blame for the vaccine mess on her then boss, then President Benigno Aquino III. According to reports, she claimed that Aquino was the one who negotiated with Sanofi Pasteur, the producer of the vaccine, in December 2015, and was the one who decided to go ahead with the immunization program.

Garin met with Sanofi in May 215 | Inquirer Opinion

[badkuk]

Interesting to note that nobody thought to sue Sanofi over this...although i would be very surprised if they didn't prepare against this --- malamang me waiver yan sa contract kaya wala silang liability.


Not to shift blame over the matter, but afaik the program was instituted at the start of the current admin. Objectors to the program could have taken the opportunity to stop it.

[kisshmet]

^the vaccine was developed due to urgency to avert an outbreak

Side effects are typical in the development of vaccines

Theres a possible problem for those innoculated in the future, theres also a sure problem for those who get infected without innoculation

This is a classic situation of damn if you do and damn if you dont

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[uls]

from what i've read, during clinical trials of Dengvaxia, Sanofi was giving the vaccine to children 5 years or younger

a lot of them seronegative

the hospitalization rate was significantly higher among those vaccinated than controls

so Sanofi knew what's happening

that's why Sanofi upped the age to 9

testing for antibodies is costly

by upping the age, there will be less dengue-naive children

didn't have to spend on antibody tests

[uls]

Dengue experts all agree that secondary dengue infection is more severe than the first

the immune reaction is what makes it worse

When a person gets infected for the first time, there are flu-like symptoms lang

When infected with another strain later (maybe years later), the immune system recognizes the 2nd dengue enough to respond but doesn't make the right antibodies

the antibodies instead help the virus enter cells and replicate more easily

The body then mounts an exaggerated immune response that causes hemorrhage and shock

basically the 1st infection enhances the 2nd infection

they call it ADE (antibody-dependent enhancement) read about it

that virus family (dengue, West Nile virus, yellow fever, Zike, Japanese encephalitis etc) is notorious for ADE

what makes the vaccine dangerous to dengue-naive subjects is that it acts as the 1st infection

the vaccine set up several thousands of people to exaggerated immune response to dengue in the future

[Yatta]

Kinakatakot ko dito baka magkaroon na rin sa Pilipinas ng mga anti-vaxxers.

[uls]

Philippines early adopter of dengue vaccine

too early

should have waited for newer dengue vaccines that can minimize effect of secondary infection

--

can't avoid thinking Big Pharma pushed it

and decision-makers in gov't had interest to make the purchase happen

[Lew_Alcindor]

Good thing may pedia advised against immediate dengue vaccination precisely due to the reason cited in the report.
Galing talaga. Sabi niya mukang effective ang dengue vaccine kung nagka-dengue ka na before. It is like the anti-bodies or whatever you got from the first infection is boosted by the vaccine. Pero kung hindi ka pa na-dengue tapos turok ng vaccine, there is nothing to boost. Kampante ka pang maglalabas hehehe

[uls]

Good thing may pedia advised against immediate dengue vaccination precisely due to the reason cited in the report.
Galing talaga. Sabi niya mukang effective ang dengue vaccine kung nagka-dengue ka na before. It is like the anti-bodies or whatever you got from the first infection is boosted by the vaccine. Pero kung hindi ka pa na-dengue tapos turok ng vaccine, there is nothing to boost. Kampante ka pang maglalabas hehehe

ganito explain sakin ng isang nerd friend

dengue meron type 1 2 3 4

pag na-infect ka for the first time (let's say type 1), your body will fight it and you'll recover fully

so meron ka na antibodies against type 1, and you also get some protection against type 2 3 4

but over time, protection against 2 3 4 will wane

but protection against type 1 will remain strong

then na-infect ka ng type 4

yung type 1 antibody can still recognize type 4 but doesn't give enough protection

but your body thinks the type 1 antibodies are handling type 4, keeps on making type 1 antibodies but type 4 isn't being neutralized

so the virus goes on replicating

[Flipo]

^the vaccine was developed due to urgency to avert an outbreak

Side effects are typical in the development of vaccines

Theres a possible problem for those innoculated in the future, theres also a sure problem for those who get infected without innoculation

This is a classic situation of damn if you do and damn if you dont

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Even Cito Beltran who supported digong in the last election, availed of this vaccine for his daughter and was very emphatic in his argument for his decision.

Sanofi, DOH allay dengue vaccine fears | Headlines, News, The Philippine Star | philstar.com