Skype is no longer in beta. It's a full functioning product. Their latest version has video capabilities.
I've been a Skype user for three years. So far, I like their service. You can do a PC to Phone call using skype but you need to subscribe to their PC2Phone service.
As far as the quality of the audio, it's subjective. I mean, there are places where I call or receive calls where the audio is either choppy or not clear. Same goes for YM with Voice).
As for security, Skype is less secure compared to NetMeeting or Cisco's VoIP solution since you need to have a number of ports open. So, for example you are running under a restrictive firewall, say Microsoft's ISA Server, then chances are Skype won't work - unless you ask your administrator to open the necessary ports. NetMeeting and Cisco, on the other hand, can work well with restrictive firewalls. We use NetMeeting at Cisco at the office, running behind a really restrictive ISA Firewall. So far, no problems.
For lags, like I said, it would be subjective. If you're gonna Skype somebody in North America or somebody in Western Europe, for example, there would be no problems since Internet lines are fast and clean. However, it's different from Skype-ing somebody from, say, places in Africa or Indonesia. I've tried Skype-ing to and from those places - very frustrating.


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