Quote Originally Posted by oj88 View Post
^ There are PC builds that calls for tiny cases like all-in-one PCs. But as you've said, if price difference is small and if the board supports M.2, go for it. It also consumes less power (however negligible). Besides, less drives on the bays means less cables to route and in many ways, promotes better airflow. Also makes for a tidier build.

Freeing up the drive bay allows you to add a secondary drive for bulk storage.

You can also use an M.2 for your boot/OS drive if you need all the SATA slots on your board.