IMO, (di naman ako pilot at zero bokya ako sa physics) the airplane will fly kahit na moving in opposite direction yung runway. by the sheer power of the airplane's engines, the engines will cut/bite into the air and the plane will fly.

yung mga VTOL (vertical take-off and landing) airplanes...di nila kailangan ang runway. pwede silang mag hover a few feet above the ground and then take-off. so immaterial kung me ground contact yung wheels nila o wala, dahil so powerful yung engines nila, magkakaroon ng lift yung wings nila kaya lilipad din sila.