I want to know which would be better.
My HU says it has 22w minx4chn (4ohm)

Is this enough to power front seps (still need to buy these) and rear 5.5" coaxials. The front seps will probably be small 4" and tweeter so I can use the factory mounting.

I don't plan on playing anything too loud. I'm just going for quality especially for long durations (on long road trips).

Eventually I'll also get a sub and I can use the pre-outs of the HU.