China Corona Virus Outbreak

[uls]

the UK and South African variants have mutations to the receptor binding domain


What we do and don't know about new COVID mutations | ABS-CBN News

Scientists have tracked multiple mutations of Sars-CoV-2, the virus that causes Covid-19, since it appeared in China in late 2019.

The vast majority of mutations did not materially alter either the virus's virulence or transmissibility.

However, one mutation -- variant B117, which likely emerged in southeastern England in September, according to Imperial College London -- has now been detected in countries across the world, including the US, France and India.

Another variant, 501.V2, was detected in South Africa in October, and has since spread to several nations, including Britain and France.

Both have multiple mutations to the virus, most notably on its spike protein -- the part of the virus that latches on to human cells and helps it spread.

Specifically, the mutated versions have an altered receptor binding domain known as N501Y, which is situated on the virus' protein spike and which allows easier access to the ACE2 receptor in human cells.

by the time dumating sa Pinas mga bakuna baka di na effective mga yan

[111prez]

China's latest potential foreign culprit of coronavirus? Auto parts packaging - CNN

First frozen seafood, now auto parts packaging

China's continuing campaign to obscure the source of the CHINA WUHAN VIRUS

[Flipo]

Report 42 - Transmission of SARS-CoV-2 Lineage B.1.1.7 in England: insights from linking epidemiological and genetic data

Report 42 - Transmission of SARS-CoV-2 Lineage B.1.1.7 in England: insights from linking epidemiological and genetic data | Faculty of Medicine | Imperial College London


New coronavirus variant spreads faster... - Hashem Al-Ghaili | Facebook

[uls]

Report 42 - Transmission of SARS-CoV-2 Lineage B.1.1.7 in England: insights from linking epidemiological and genetic data

Report 42 - Transmission of SARS-CoV-2 Lineage B.1.1.7 in England: insights from linking epidemiological and genetic data | Faculty of Medicine | Imperial College London


New coronavirus variant spreads faster... - Hashem Al-Ghaili | Facebook

this is from the link you posted

alam mo ung S-gene target failure?

Summary

The SARS-CoV-2 lineage B.1.1.7, now designated Variant of Concern 202012/01 (VOC) by Public Health England, originated in the UK in late Summer to early Autumn 2020. We examine epidemiological evidence for this VOC having a transmission advantage from several perspectives. First, whole genome sequence data collected from community-based diagnostic testing provides an indication of changing prevalence of different genetic variants through time. Phylodynamic modelling additionally indicates that genetic diversity of this lineage has changed in a manner consistent with exponential growth. Second, we find that changes in VOC frequency inferred from genetic data correspond closely to changes inferred by S-gene target failures (SGTF) in community-based diagnostic PCR testing. Third, we examine growth trends in SGTF and non-SGTF case numbers at local area level across England, and show that the VOC has higher transmissibility than non-VOC lineages, even if the VOC has a different latent period or generation time. Available SGTF data indicate a shift in the age composition of reported cases, with a larger share of under 20 year olds among reported VOC than non-VOC cases.

the S gene is the spike gene

the B117 lineage has a mutation where there's a deletion at spike amino acid positions 69 and 70

sa PCR test they look for parts of the virus not the whole virus

test kits usually look for 2 or 3 genes

N - nucleocapsid, ORF - open reading frame, S - spike

ang nangyari napansin ng mga lab sa UK madami nag negative sa S gene pero positive sa ibang gene/s ng SARSCOV2

so by accident, PCR tests that use S gene primer/probe can be used to screen for the UK variant

dunno if our PCR labs are aware of this

mahal mag whole genome sequencing palagi

S gene target failure can be used to alert labs that they have a strange variant and that sample should be sequenced

[dr. d]

yespo.
our local scientists are aware of it.
they talk to one another, here and abroad, on a regular basis.

[111prez]

Hong Kong: Traveler from Philippines had UK variant of COVID-19

Pasahero galing Pilipinas nagpositibo sa bagong COVID variant sa HK | ABS-CBN News

Whoa, the new variant of the CHINA WUHAN VIRUS was already here since December.

[Monseratto]

MMDA chief Danny Lim dies

The head of MMDA, one of the government agencies working in the frontlines amid the pandemic, contracted COVID-19 in late December. He said his symptoms were mild.

[111prez]

WHO 'disappointed' at Chinese delays letting experts in

WHO is just disapppointed while the whole world continues to suffer from the CHINA WUHAN VIRUS

[Monseratto]

Japan's daily coronavirus cases top 6, 000 for 1st time


85% of Malaysia's hospital beds for Covid-19 patients filled, as new daily cases hit high, SE Asia News & Top Stories - The Straits Times

[_Cathy_]

I'm slowly normalizing my life na nga and then this happens. Even if I want to isolate again, less na nago offer na deliveries. For example yung mga binibilhan ko ng fruits and vegetables. I guess dahil traffic na at bihira na rin mga nagpapa deliver kasi karamihan lumalabas na.

[Monseratto]

JUST IN: Former Oriental Mindoro Rep. Reynaldo Umali has died due to cardiac arrest, days after he was diagnosed with COVID-19 and cancer, his brother Rep. Alfonso Umali says in a radio interview

[111prez]

JUST IN: Former Oriental Mindoro Rep. Reynaldo Umali has died due to cardiac arrest, days after he was diagnosed with COVID-19 and cancer, his brother Rep. Alfonso Umali says in a radio interview

Will this be reported as a CHINA WUHAN VIRUS death or not? How did they report the death of MMDA Chair Lim?

[dr. d]

JUST IN: Former Oriental Mindoro Rep. Reynaldo Umali has died due to cardiac arrest, days after he was diagnosed with COVID-19 and cancer, his brother Rep. Alfonso Umali says in a radio interview

so he died because his heart stopped beating.
but what caused the heart to stop beating in the first place?

sorry, folks.
my pet peeve...

[111prez]

so he died because his heart stopped beating.
but what caused the heart to stop beating in the first place?

sorry, folks.
my pet peeve...

If you were in the place of the authorities doc, how would you report this? Death due to CHINA WUHAN VIRUS or heart attack?

[dr. d]

If you were in the place of the authorities doc, how would you report this? Death due to CHINA WUHAN VIRUS or heart attack?

i don't know.
he may have had the virus, but that does not mean he died as a result of its complications.
conversely, just because a person has no known history of heart disease, does not mean he did not die of heart attack.
a doctor informed of his condition, including the details of his death, would be in a better position to determine cause of death.

my point is this: it is not usually correct to say a person died because his heart stopped ("cardiac arrest").
some writers believe that writing down cardiac arrest as the cause of death, is wrong.
they feel that cardiac arrest is evidence of death, and not cause of death.

[111prez]

Taiwan news report claims Sinopharm has 73 side effects; PH experts weigh in | ABS-CBN News

[dr. d]

the mis-behavior of the humans, may not have nuthin' to do with the vaccines' usefulness or non-usefulness.
"they're businessmen, not scientists."

my opinion.

[Monseratto]

US breaks 4,000 daily COVID deaths in 24 hours record...

[Monseratto]

From Viber page regarding owner of Chocnut.

The need to be continuously careful during this pandemic cannot be emphasized too much. The business community has surely heard of the passing of the owner of Chocnut. His son is a good friend of my brother in law. In spite of all our warnings and having an 84 year old father at home my brother in law continued to say the virus is nothing and constantly was at the house of his friend. His friend came down with covid allegedly getting it from his stay out driver passed it to his wife, dad and mom and my brother in law. Because of that and with some in laws visiting my father in law a small panic ensued requiring testing of everyone involved and voluntary self quarantined for those with symptoms. The owner of Chocnut succumbed after two days in the hospital in spite of convalescent plasma transfusions and other medications because he also had a heart condition. These are high risk activities which I would advise against:
1. Don't visit or accept visitors to your home
2. Eating out in enclosed restaurants with people not keeping social distancing
3. Going to enclosed spaces frequented by a lot of people esp without face mask or shield
4. Drinking laughing together in groups karaoke in groups
5. Bringing children out in spite of the gcq. Children may be liwcrisk for severe covid symptoms but they act as carriers more than adults and bring the disease back to adults at home
I know everyone is bored with staying at home and not being able to enjoy their favourite restaurants or visit their friends. But as you've seen in our case or have experienced yourself, when you or someone close to you gets sick it is not only that person who is at risk but others around them.
A friendly reminder to all. This thing is not yet over even when a vaccine is in place. The vaccine doesn't mean you are totally protected or not infective still. 40 percent of the population must be vaccinated before a herd immunity can occur. Also remember that people who got over the virus do not necessarily have permanent immunity. We have had many employees get infected. A study in UK at Oxford showed that antibody levels in people who recovered from covid start dropping after three months keep safe all!

[Monseratto]

Considering Gen. Lim could be called a health buff...

Sharing with the backgrounder account on how Danny Lim contracted the Covid Virus. This acct is by my close lawyer friend who was Danny Lim's Counselor during his trial for many cases for his participation in the coup vs GMA:

"Fellow RCMGers: I know Danny (Rtn. Danny Lim) personally. I was his sole lawyer before various military tribunals for the so many cases filed against him under Articles of War and before Makati RTC 150 in connection with the Feb. 24, 2006 coup against Macapagal Arroyo and the Peninsula escapade with Rtn. Sonny. I knew him to be healthy: he was not diabetic, did not smoke, not hypertensive, and did not drink as much as I do, and had the right disposition in life. In fact, he avoided drinking even while he was detained in Camp Capinpin, Tanay. And he was a runner. He exercised almost everyday. Last Dec 23, he met with some of his Mason bros. On Dec 24, he had fever. He had noche buena with family last Dec 25 as the fever had receded. But on Dec 26, fever was up again but he ignored it so that on Dec 28 he went to office at MMDA and had a swab test later. He was brought to St. Luke’s the following day because “mainit na buong katawan niya.” Swab test result came day after, it was positive. He had pneumoia due to covid but he was cured of it. But COVID affected his liver so he had to undergo dialysis. But he made it. He was on the way to recovery, so the doctors thought. Early this morning, he suffered from a heart attack, a fatal one. His liver was the trigger. Why this narrative? Just to say that even if you are healthy it is no guaranty that you will triumph over this COVIDevil. KAYA INGAT INGAT SUPER INGAT"