Not really. When I use a bigger monitor I increase the viewing distance. My eyes tend to focus less with a bigger screen, so there's less strain. With the increased viewing distance, the eye movement should be just about the same.
Unless you're near-sighted and have to place a 40" monitor 1 foot away.
im using a acer 19" widescreen LCD and 2-3 feet lang ang distance ko from the monitor since im near sighted .. so far for the last 2 years ok naman .. sanayan lang cguro ..