urethane is not really more difficult to apply - it's just more steps since it's basecoat/clearcoat. basecoat needs only to cover and be the right color, while clearcoat adds the shine and protection, and needs to be nice, wet and even (but not too wet or it will run).

you can also buff out urethane much more easily if you have imperfections, or later on when the paint job needs sprucing up.

urethane is also much more durable and less prone to cracking than acrylic