I had a Pioneer 2850 installed in my wife's Innova. Not sure if they have the same software as the 5850, but with the 2850 Spotify & Waze works.
For the waze to work, you need to down load some pioneer apps in your smartphone & just sign in for it to appear in your head unit. You'll be controlling you waze thru the head unit as the would be sort of blank. It would be a bit sluggish though compared to the waze on your phone so better type in your route na in your phone before plugging it in your head unit.
Spotify also works & you can control it either thru the head unit or steering wheel controls.
I had to purchase a separate steering wheel adapter (around P2k I think) for it to work. You just have to program the head unit to match the buttons in the steering wheel.